Definition of bladder cancer: Cancer that forms in tissues of the bladder (the organ that stores urine). Most bladder cancers are transitional cell carcinomas (cancer that begins in cells that normally make up the inner lining of the bladder). Other types include squamous cell carcinoma (cancer that begins in thin, flat cells) and adenocarcinoma (cancer that begins in cells that make and release mucus and other fluids). The cells that form squamous cell carcinoma and adenocarcinoma develop in the inner lining of the bladder as a result of chronic irritation and inflammation.
Estimated new cases and deaths from bladder cancer in the United States in 2010:

Bladder cancer is a cancerous tumor in the bladder. The bladder is the organ in the center of the lower abdomen that holds urine. Causes, incidence, and risk factors In the United States, bladder cancers usually start from the cells lining the bladder (transitional cells). These tumors are classified based on the way they grow: · Papillary tumors have a wart-like appearance and are attached to a stalk. · Nonpapillary (sessile) tumors are much less common. However, they are more invasive and have a worse outcome. As with most other cancers, the exact cause of bladder cancer is uncertain. However, several factors may contribute to its development: · Cigarette smoking. Smoking increases the risk of developing bladder cancer nearly fivefold. As many as 50% of all bladder cancers in men and 30% in women may be caused by cigarette smoke. People who quit smoking have a gradual decline in risk. · Chemical exposure at work. About one in four cases of bladder cancer is caused by exposure to cancer-causing chemicals (carcinogens) on the job. Dye workers, rubber workers, aluminum workers, leather workers, truck drivers, and pesticide applicators are at the highest risk. Arylamines are the chemicals most responsible. However, arylamines have been reduced or eliminated in many workplaces. · Radiation and chemotherapy. Women who received radiation therapy for the treatment of cervical cancer have an increased risk of developing transitional cell bladder cancer. Some people who have received the chemotherapy drug cyclophosphamide (Cytoxan) are also at increased risk. · Bladder infection. A long-term (chronic) bladder infection or irritation may lead to the development of squamous cell bladder cancer. Bladder infections do not increase the risk of transitional cell cancers. · Parasite infection. Infection with the schistosomiasis parasite has been linked to the development of bladder cancer. The association between artificial sweeteners and bladder cancer has been studied and is weak or nonexistent. Bladder cancers are classified, or staged, based on their aggressiveness and how much they differ from the surrounding bladder tissue. There are several different ways to stage tumors. Recently, the TNM (Tumor, Nodes, Metastasis) staging system has become common. This staging system categorizes tumors using the following scale: · Stage 0 -- Noninvasive tumors that are only in the bladder lining · Stage I -- Tumor goes through the bladder lining, but does not reach the muscle layer of the bladder · Stage II -- Tumor goes into the muscle layer of the bladder · Stage III -- Tumor goes past the muscle layer into tissue surrounding the bladder · Stage IV -- Tumor has spread to neighboring lymph nodes or to distant sites (metastatic disease) Bladder cancer spreads by extending into the nearby organs, including the: · Prostate · Rectum · Ureters · Uterus · Vagina It can also spread to lymph nodes in the pelvis, or to other parts of the body, such as: · Bones · Liver · Lungs Symptoms Most of the symptoms of bladder cancer can also occur with non-cancerous conditions. It's important to get evaluated if you have any of these symptoms: · Blood in the urine · Painful urination · Urinary frequency · Urinary urgency Other symptoms that can occur with this disease: · Abdominal pain · Anemia · Bone pain or tenderness · Lethargy or fatigue · Urinary incontinence · Weight loss | |
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